Application
TNFRSF21 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TNFRSF21 antibody detected the TNFRSF21 protein (arrow).| Product Name | TNFRSF21 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DR6 |
|---|---|
| Alternative Names | TNFRSF21 DR6 Tumor necrosis factor receptor superfamily member 21 Death receptor 6 CD_antigen=CD358 Flags: Precursor |
| Molecular Weight(MW) | 71845 Da |
| Function | May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N- terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) |
| Tissue Specificity | Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes |
| Cellular Localization | Membrane; Single-pass type I membrane protein (Probable) |
| Entrez Gene | 27242 |
|---|---|
| Nucleotide Accession | NP_055267.1 |
Application
TNFRSF21 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TNFRSF21 antibody detected the TNFRSF21 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
