Application
TNIP2 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the TNIP2 antibody detected the TNIP2 protein (arrow).| Product Name | TNIP2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TNIP2; ABIN2; FLIP1; TNFAIP3-interacting protein 2; A20-binding inhibitor of NF-kappa-B activation 2; Fetal liver LKB1-interacting protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ABIN2 FLIP1 |
|---|---|
| Alternative Names | TNIP2 ABIN2 FLIP1 TNFAIP3-interacting protein 2 A20-binding inhibitor of NF-kappa-B activation 2 Fetal liver LKB1-interacting protein |
| Molecular Weight(MW) | 48700 Da |
| Function | Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes |
| Tissue Specificity | Ubiquitously expressed in all tissues examined |
| Cellular Localization | Cytoplasm. Nucleus (Probable). |
| Entrez Gene | 79155 |
|---|---|
| Nucleotide Accession | NP_001154999.1 NP_077285.3 |
Application
TNIP2 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the TNIP2 antibody detected the TNIP2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
