Application
TNPO2 Antibody (N-term) western blot analysis in A2058,HepG2,MCF-7,MDA-MB435 cell line lysates (35ug/lane).This demonstrates the TNPO2 antibody detected the TNPO2 protein (arrow).| Product Name | TNPO2 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TNPO2; Transportin-2; Karyopherin beta-2b |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | TNPO2 Transportin-2 Karyopherin beta-2b |
|---|---|
| Molecular Weight(MW) | 101388 Da |
| Function | Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity) |
| Tissue Specificity | This TNPO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 320~349 amino acids from the N-terminal region of human TNPO2. |
| Cellular Localization | Cytoplasm (By similarity). Nucleus (By similarity) |
| Entrez Gene | 30000 |
|---|
Application
TNPO2 Antibody (N-term) western blot analysis in A2058,HepG2,MCF-7,MDA-MB435 cell line lysates (35ug/lane).This demonstrates the TNPO2 antibody detected the TNPO2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
