Application
Western blot analysis on (A) fetal brain and (B) C6 cell lysates using anti-TORC-1 RabMAb (Cat. #AJ1781a).| Product Name | TORC-1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CRTC1, KIAA0616, MECT1, TORC1, WAMTP1, CREB-regulated transcription coactivator 1, Mucoepidermoid carcinoma translocated protein 1 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EPR3382 |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:10000~20000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0616 MECT1 TORC1 WAMTP1 |
|---|---|
| Alternative Names | CRTC1 KIAA0616 MECT1 TORC1 WAMTP1 CREB-regulated transcription coactivator 1 Mucoepidermoid carcinoma translocated protein 1 |
| Molecular Weight(MW) | 67300 Da |
| Function | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity) |
| Tissue Specificity | Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney |
| Cellular Localization | Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels |
| Entrez Gene | 23373 |
|---|
Application
Western blot analysis on (A) fetal brain and (B) C6 cell lysates using anti-TORC-1 RabMAb (Cat. #AJ1781a).| Application Notes | WB:1:10000~20000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
