Application
A. Western blot analysis on Jurkat cell lysate using anti-Tpl2 RabMAb (Cat. #AJ1785a), dilution 1:500.| Product Name | Tpl2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Map3k8, Tpl2, Mitogen-activated protein kinase kinase kinase 8, Tumor progression locus 2 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP1103Y |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | COT ESTF |
|---|---|
| Alternative Names | Map3k8 Tpl2 Mitogen-activated protein kinase kinase kinase 8 Tumor progression locus 2 |
| Molecular Weight(MW) | 52925 Da |
| Function | Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein |
| Tissue Specificity | Expressed in several normal tissues and human tumor-derived cell lines |
| Cellular Localization | Cytoplasm. |
| Entrez Gene | 1326 |
|---|
Application
A. Western blot analysis on Jurkat cell lysate using anti-Tpl2 RabMAb (Cat. #AJ1785a), dilution 1:500.| Application Notes | WB:1:500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
