Application
Western blot analysis of anti-TERF1(C-term) Pab in Jurkat cell line lysates (35ug/lane). TERF1(C-term)(arrow) was detected using the purified Pab (1:60dilution).| Product Name | TRF (TERF1) Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TERF1; PIN2; TRBF1; TRF; TRF1; Telomeric repeat-binding factor 1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PIN2 TRBF1 TRF TRF1 |
|---|---|
| Alternative Names | TERF1 PIN2 TRBF1 TRF TRF1 Telomeric repeat-binding factor 1 NIMA-interacting protein 2 TTAGGG repeat-binding factor 1 Telomeric protein Pin2/TRF1 |
| Molecular Weight(MW) | 50246 Da |
| Function | Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways |
| Tissue Specificity | Highly expressed and ubiquitous. Isoform Pin2 predominates |
| Cellular Localization | Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle |
| Entrez Gene | 7013 |
|---|
Application
Western blot analysis of anti-TERF1(C-term) Pab in Jurkat cell line lysates (35ug/lane). TERF1(C-term)(arrow) was detected using the purified Pab (1:60dilution).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
