Application
TRIM22 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TRIM22 antibody detected the TRIM22 protein (arrow).| Product Name | TRIM22 (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TRIM22; RNF94; STAF50; E3 ubiquitin-protein ligase TRIM22; 50 kDa-stimulated trans-acting factor; RING finger protein 94; Staf-50; Tripartite motif-containing protein 22 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | RNF94 STAF50 |
|---|---|
| Alternative Names | TRIM22 RNF94 STAF50 E3 ubiquitin-protein ligase TRIM22 50 kDa-stimulated trans-acting factor RING finger protein 94 Staf-50 Tripartite motif-containing protein 22 |
| Molecular Weight(MW) | 56947 Da |
| Function | Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity |
| Tissue Specificity | Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues |
| Cellular Localization | Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominanltly into the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies |
| Entrez Gene | 10346 |
|---|---|
| Nucleotide Accession | NP_006065.2 |
Application
TRIM22 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TRIM22 antibody detected the TRIM22 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
