Application
TRIM13 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TRIM13 antibody detected the TRIM13 protein (arrow).| Product Name | TRIM13 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TRIM13; LEU5; RFP2; RNF77; E3 ubiquitin-protein ligase TRIM13; B-cell chronic lymphocytic leukemia tumor suppressor Leu5; Leukemia-associated protein 5; Putative tumor suppressor RFP2; RING finger protein 77; Ret finger protein 2; Tripartite motif-containi |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | LEU5 RFP2 RNF77 |
|---|---|
| Alternative Names | TRIM13 LEU5 RFP2 RNF77 E3 ubiquitin-protein ligase TRIM13 B-cell chronic lymphocytic leukemia tumor suppressor Leu5 Leukemia-associated protein 5 Putative tumor suppressor RFP2 RING finger protein 77 Ret finger protein 2 Tripartite motif-containi |
| Molecular Weight(MW) | 46988 Da |
| Function | E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD) This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor |
| Tissue Specificity | This TRIM13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-90 amino acids from the N-terminal region of human TRIM13. |
| Cellular Localization | Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum |
| Entrez Gene | 10206 |
|---|---|
| Nucleotide Accession | NP_005789.2 NP_434698.1 NP_001007279.1 NP_998755.1 |
Application
TRIM13 Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TRIM13 antibody detected the TRIM13 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
