Application
TRPM4 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TRPM4 antibody detected the TRPM4 protein (arrow).| Product Name | TRPM4 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TRPM4; LTRPC4; Transient receptor potential cation channel subfamily M member 4; Calcium-activated non-selective cation channel 1; Long transient receptor potential channel 4; Melastatin-4 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | LTRPC4 |
|---|---|
| Alternative Names | TRPM4 LTRPC4 Transient receptor potential cation channel subfamily M member 4 Calcium-activated non-selective cation channel 1 Long transient receptor potential channel 4 Melastatin-4 |
| Molecular Weight(MW) | 134301 Da |
| Function | Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway |
| Tissue Specificity | Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells |
| Cellular Localization | Isoform 1: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus |
| Entrez Gene | 54795 |
|---|---|
| Nucleotide Accession | NP_001182156.1 NP_060106.2 |
Application
TRPM4 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TRPM4 antibody detected the TRPM4 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
