Application
TRPV4 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TRPV4 antibody detected the TRPV4 protein (arrow).| Product Name | TRPV4 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TRPV4; VRL2; VROAC; Transient receptor potential cation channel subfamily V member 4; Osm-9-like TRP channel 4; Transient receptor potential protein 12; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; Vanilloid receptor-related osmoti |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | VRL2 VROAC |
|---|---|
| Alternative Names | TRPV4 VRL2 VROAC Transient receptor potential cation channel subfamily V member 4 Osm-9-like TRP channel 4 Transient receptor potential protein 12 Vanilloid receptor-like channel 2 Vanilloid receptor-like protein 2 Vanilloid receptor-related osmoti |
| Molecular Weight(MW) | 98281 Da |
| Function | Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 |
| Tissue Specificity | Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level) |
| Cellular Localization | Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, adherens junction (By similarity) Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum Isoform 5: Cell membrane. |
| Entrez Gene | 59341 |
|---|---|
| Nucleotide Accession | NP_067638.3 |
Application
TRPV4 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TRPV4 antibody detected the TRPV4 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
