Application
TRPV6 Antibody (C-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the TRPV6 antibody detected the TRPV6 protein (arrow).| Product Name | TRPV6 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TRPV6; ECAC2; Transient receptor potential cation channel subfamily V member 6; CaT-like; Calcium transport protein 1; Epithelial calcium channel 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ECAC2 |
|---|---|
| Alternative Names | TRPV6 ECAC2 Transient receptor potential cation channel subfamily V member 6 CaT-like Calcium transport protein 1 Epithelial calcium channel 2 |
| Molecular Weight(MW) | 83210 Da |
| Function | Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity) |
| Tissue Specificity | Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia |
| Cellular Localization | Cell membrane; Multi-pass membrane protein (By similarity) |
| Entrez Gene | 55503 |
|---|---|
| Nucleotide Accession | NP_061116.2 |
Application
TRPV6 Antibody (C-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the TRPV6 antibody detected the TRPV6 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
