Application
TSC22D3 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the TSC22D3 antibody detected the TSC22D3 protein (arrow).| Product Name | TSC22D3 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TSC22D3; DSIPI; GILZ; TSC22 domain family protein 3; DSIP-immunoreactive peptide; Delta sleep-inducing peptide immunoreactor; Glucocorticoid-induced leucine zipper protein; TSC-22-like protein; TSC-22-related protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DSIPI GILZ |
|---|---|
| Alternative Names | TSC22D3 DSIPI GILZ TSC22 domain family protein 3 DSIP-immunoreactive peptide Delta sleep-inducing peptide immunoreactor Glucocorticoid-induced leucine zipper protein TSC-22-like protein TSC-22-related protein |
| Molecular Weight(MW) | 14810 Da |
| Function | Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity) |
| Tissue Specificity | Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down- regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells |
| Entrez Gene | 1831 |
|---|---|
| Nucleotide Accession | NP_004080.2 NP_001015881.1 |
Application
TSC22D3 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the TSC22D3 antibody detected the TSC22D3 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
