Application
TTC8 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TTC8 antibody detected the TTC8 protein (arrow).| Product Name | TTC8 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TTC8; BBS8; Tetratricopeptide repeat protein 8; Bardet-Biedl syndrome 8 protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BBS8 |
|---|---|
| Alternative Names | TTC8 BBS8 Tetratricopeptide repeat protein 8 Bardet-Biedl syndrome 8 protein |
| Molecular Weight(MW) | 61534 Da |
| Function | The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane |
| Tissue Specificity | Widely expressed. |
| Cellular Localization | Cytoplasm, cytoskeleton, centrosome. Cell projection, cilium membrane. Cytoplasm. Note=Localizes to nonmembranous centriolar satellites in the cytoplasm |
| Entrez Gene | 123016 |
|---|---|
| Nucleotide Accession | NP_938051.1 NP_653197.2 |
Application
TTC8 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TTC8 antibody detected the TTC8 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
