Application
TTLL5 Antibody (Center) western blot analysis in U251 cell line lysates (15ug/lane).This demonstrates the TTLL5 antibody detected the TTLL5 protein (arrow).Application
TTLL5 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TTLL5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | TTLL5 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TTLL5; KIAA0998; STAMP; Tubulin polyglutamylase TTLL5; SRC1 and TIF2-associated modulatory protein; Tubulin--tyrosine ligase-like protein 5 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0998 STAMP |
|---|---|
| Alternative Names | TTLL5 KIAA0998 STAMP Tubulin polyglutamylase TTLL5 SRC1 and TIF2-associated modulatory protein Tubulin--tyrosine ligase-like protein 5 |
| Molecular Weight(MW) | 143577 Da |
| Function | Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction |
| Tissue Specificity | Widely expressed with highest levels in heart and skeletal muscle and low levels in other tissues |
| Cellular Localization | Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity) Nucleus. Cytoplasm. Note=In ciliated cells, located in both cilia and basal bodies (By similarity). In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid |
| Entrez Gene | 23093 |
|---|---|
| Nucleotide Accession | NP_055887.3 |
Application
TTLL5 Antibody (Center) western blot analysis in U251 cell line lysates (15ug/lane).This demonstrates the TTLL5 antibody detected the TTLL5 protein (arrow).
Application
TTLL5 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TTLL5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
