Application
TXNRD1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TXNRD1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.Application
TXNRD1 Antibody (N-term) western blot analysis in NCI-H292,Jurkat cell line lysates (35ug/lane).This demonstrates the TXNRD1 antibody detected the TXNRD1 protein (arrow).| Product Name | TXNRD1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TXNRD1; GRIM12; KDRF; Thioredoxin reductase 1, cytoplasmic; Gene associated with retinoic and interferon-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| IHC:1:10~50 WB |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | GRIM12 KDRF |
|---|---|
| Alternative Names | TXNRD1 GRIM12 KDRF Thioredoxin reductase 1 cytoplasmic Gene associated with retinoic and interferon-induced mortality 12 protein KM-102-derived reductase-like factor Thioredoxin reductase TR1 |
| Molecular Weight(MW) | 70906 Da |
| Function | Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid |
| Tissue Specificity | Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver |
| Cellular Localization | Cytoplasm (By similarity). Isoform 5: Cytoplasm. |
| Entrez Gene | 7296 |
|---|---|
| Nucleotide Accession | NP_003321.3 |
Application
TXNRD1 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TXNRD1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
TXNRD1 Antibody (N-term) western blot analysis in NCI-H292,Jurkat cell line lysates (35ug/lane).This demonstrates the TXNRD1 antibody detected the TXNRD1 protein (arrow).| Application Notes | IHC:1:10~50 WB |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
