Application
UBASH3A Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the UBASH3A antibody detected the UBASH3A protein (arrow).| Product Name | UBASH3A Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | UBASH3A; STS2; Ubiquitin-associated and SH3 domain-containing protein A; Cbl-interacting protein 4; Suppressor of T-cell receptor signaling 2; T-cell ubiquitin ligand 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | STS2 |
|---|---|
| Alternative Names | UBASH3A STS2 Ubiquitin-associated and SH3 domain-containing protein A Cbl-interacting protein 4 Suppressor of T-cell receptor signaling 2 T-cell ubiquitin ligand 1 |
| Molecular Weight(MW) | 74123 Da |
| Function | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain |
| Tissue Specificity | Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow |
| Cellular Localization | Cytoplasm. Nucleus. |
| Entrez Gene | 53347 |
|---|---|
| Nucleotide Accession | NP_061834.1 |
Application
UBASH3A Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the UBASH3A antibody detected the UBASH3A protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
