Application
UBP37 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the UBP37 antibody detected the UBP37 protein (arrow).| Product Name | UBP37 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | USP37; KIAA1594; Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinating enzyme 37; Ubiquitin thioesterase 37; Ubiquitin-specific-processing protease 37 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1594 |
|---|---|
| Alternative Names | USP37 KIAA1594 Ubiquitin carboxyl-terminal hydrolase 37 Deubiquitinating enzyme 37 Ubiquitin thioesterase 37 Ubiquitin-specific-processing protease 37 |
| Molecular Weight(MW) | 110170 Da |
| Function | Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'- linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) |
| Tissue Specificity | Expressed in brain and prostate. |
| Entrez Gene | 57695 |
|---|---|
| Nucleotide Accession | NP_065986.2 |
Application
UBP37 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the UBP37 antibody detected the UBP37 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
