Application
ULBP2 Antibody (Center) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the ULBP2 antibody detected the ULBP2 protein (arrow).Application
Western blot analysis of ULBP2 (arrow) using rabbit polyclonal ULBP2 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ULBP2 gene.| Product Name | ULBP2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ULBP2; N2DL2; RAET1H; NKG2D ligand 2; ALCAN-alpha; Retinoic acid early transcript 1H; UL16-binding protein 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | N2DL2 RAET1H |
|---|---|
| Alternative Names | ULBP2 N2DL2 RAET1H NKG2D ligand 2 ALCAN-alpha Retinoic acid early transcript 1H UL16-binding protein 2 |
| Molecular Weight(MW) | 27368 Da |
| Function | Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis- Golgi apparatus so that it does not reach the cell surface |
| Tissue Specificity | Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor. Secreted |
| Entrez Gene | 80328 |
|---|---|
| Nucleotide Accession | NP_079493.1 |
Application
ULBP2 Antibody (Center) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the ULBP2 antibody detected the ULBP2 protein (arrow).
Application
Western blot analysis of ULBP2 (arrow) using rabbit polyclonal ULBP2 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ULBP2 gene.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
