Application
UNC84B Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the UNC84B antibody detected the UNC84B protein (arrow).| Product Name | UNC84B Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SUN2; FRIGG; KIAA0668; RAB5IP; UNC84B; SUN domain-containing protein 2; Protein unc-84 homolog B; Rab5-interacting protein; Sad1/unc-84 protein-like 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FRIGG KIAA0668 RAB5IP UNC84B |
|---|---|
| Alternative Names | SUN2 FRIGG KIAA0668 RAB5IP UNC84B SUN domain-containing protein 2 Protein unc-84 homolog B Rab5-interacting protein Sad1/unc-84 protein-like 2 |
| Molecular Weight(MW) | 80311 Da |
| Function | Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5 |
| Tissue Specificity | Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects |
| Cellular Localization | Nucleus inner membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein (Probable) |
| Entrez Gene | 25777 |
|---|---|
| Nucleotide Accession | NP_056189.1 |
Application
UNC84B Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the UNC84B antibody detected the UNC84B protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
