Application
USP20 Antibody (E828) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the USP20 antibody detected the USP20 protein (arrow).Application
USP20 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of USP20 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | USP20 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | USP20; KIAA1003; LSFR3A; VDU2; Ubiquitin carboxyl-terminal hydrolase 20; Deubiquitinating enzyme 20; Ubiquitin thioesterase 20; Ubiquitin-specific-processing protease 20; VHL-interacting deubiquitinating enzyme 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1003 LSFR3A VDU2 |
|---|---|
| Alternative Names | USP20 KIAA1003 LSFR3A VDU2 Ubiquitin carboxyl-terminal hydrolase 20 Deubiquitinating enzyme 20 Ubiquitin thioesterase 20 Ubiquitin-specific-processing protease 20 VHL-interacting deubiquitinating enzyme 2 |
| Molecular Weight(MW) | 102003 Da |
| Function | Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2 This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains |
| Tissue Specificity | This USP20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 821~850 amino acids from the C-terminal region of human USP20. |
| Cellular Localization | Cytoplasm, perinuclear region (By similarity). Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear |
Application
USP20 Antibody (E828) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the USP20 antibody detected the USP20 protein (arrow).
Application
USP20 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of USP20 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
