Application
USP17L2 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the USP17L2 antibody detected the USP17L2 protein (arrow).| Product Name | USP17L2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | USP17L2 DUB3 Ubiquitin carboxyl-terminal hydrolase 17-like protein 2 Deubiquitinating enzyme 17-like protein 2 Deubiquitinating protein 3 Ubiquitin thioesterase 17-like protein 2 Ubiquitin-specific-processing protease 17-like protein 2 |
|---|---|
| Molecular Weight(MW) | 59619 Da |
| Function | Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection |
| Tissue Specificity | Broadly expressed. |
| Cellular Localization | Nucleus. Endoplasmic reticulum. |
| Entrez Gene | 377630 |
|---|---|
| Nucleotide Accession | NP_958804.2 |
Application
USP17L2 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the USP17L2 antibody detected the USP17L2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
