Application
USP4 Antibody (N-term) western blot analysis in human uterine tumor tissue lysates (35ug/lane).This demonstrates the USP4 antibody detected the USP4 protein (arrow).Application
USP4 Antibody (N-term) (AP14657a)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of USP4 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | USP4 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | USP4; UNP; UNPH; Ubiquitin carboxyl-terminal hydrolase 4; Deubiquitinating enzyme 4; Ubiquitin thioesterase 4; Ubiquitin-specific-processing protease 4; Ubiquitous nuclear protein homolog |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | UNP UNPH |
|---|---|
| Alternative Names | USP4 UNP UNPH Ubiquitin carboxyl-terminal hydrolase 4 Deubiquitinating enzyme 4 Ubiquitin thioesterase 4 Ubiquitin-specific-processing protease 4 Ubiquitous nuclear protein homolog |
| Molecular Weight(MW) | 108565 Da |
| Function | Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in the regulation of quality control in the ER |
| Tissue Specificity | Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons |
| Cellular Localization | Cytoplasm (By similarity). Nucleus (By similarity). Note=Shuttles between the nucleus and cytoplasm Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type (By similarity) |
| Entrez Gene | 7375 |
|---|---|
| Nucleotide Accession | NP_003354.2 NP_955475.1 |
Application
USP4 Antibody (N-term) western blot analysis in human uterine tumor tissue lysates (35ug/lane).This demonstrates the USP4 antibody detected the USP4 protein (arrow).
Application
USP4 Antibody (N-term) (AP14657a)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of USP4 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
