Application
VPS39 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the VPS39 antibody detected the VPS39 protein (arrow).| Product Name | VPS39 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0770, TLP, VAM6 |
|---|---|
| Alternative Names | VPS39 KIAA0770 VAM6 Vam6/Vps39-like protein |
| Molecular Weight(MW) | 101809 Da |
| Function | May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation |
| Tissue Specificity | Widely expressed, with highest levels in heart, skeletal muscle, kidney, pancreas, brain, placenta and spleen |
| Cellular Localization | Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles |
| Entrez Gene | 23339 |
|---|---|
| Nucleotide Accession | NP_056104.2 |
Application
VPS39 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the VPS39 antibody detected the VPS39 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
