Application
XRCC4 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the XRCC4 antibody detected the XRCC4 protein (arrow).| Product Name | XRCC4 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | XRCC4; DNA repair protein XRCC4; X-ray repair cross-complementing protein 4 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | XRCC4 DNA repair protein XRCC4 X-ray repair cross-complementing protein 4 |
|---|---|
| Molecular Weight(MW) | 38287 Da |
| Function | Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends |
| Tissue Specificity | Widely expressed. |
| Cellular Localization | Nucleus. |
| Entrez Gene | 7518 |
|---|---|
| Nucleotide Accession | NP_003392.1 |
Application
XRCC4 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the XRCC4 antibody detected the XRCC4 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
