Application
ZBTB7A Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the ZBTB7A antibody detected the ZBTB7A protein (arrow).Application
ZBTB7A Antibody (C-term) (AP14208b)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ZBTB7A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | ZBTB7A Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FBI1, LRF, ZBTB7, ZNF857A |
|---|---|
| Alternative Names | ZBTB7A FBI1 LRF ZBTB7 ZNF857A Zinc finger and BTB domain-containing protein 7A Factor binding IST protein 1 Factor that binds to inducer of short transcripts protein 1 HIV-1 1st-binding protein 1 Leukemia/lymphoma-related factor POZ and Krueppel |
| Molecular Weight(MW) | 61439 Da |
| Function | Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity) |
| Tissue Specificity | Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level) |
| Cellular Localization | Nucleus (By similarity). |
| Entrez Gene | 51341 |
|---|---|
| Nucleotide Accession | NP_056982.1 |
Application
ZBTB7A Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the ZBTB7A antibody detected the ZBTB7A protein (arrow).
Application
ZBTB7A Antibody (C-term) (AP14208b)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ZBTB7A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
