Application
ZC12A Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ZC12A antibody detected the ZC12A protein (arrow).Application
ZC12A antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human spleen tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ZC12A antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.Application
ZC12A Antibody (Center) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Product Name | ZC12A Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHCFC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | MCPIP, MCPIP1 |
|---|---|
| Alternative Names | ZC3H12A MCPIP MCPIP1 Ribonuclease ZC3H12A MCP-induced protein 1 Zinc finger CCCH domain-containing protein 12A |
| Molecular Weight(MW) | 65699 Da |
| Function | Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19 |
| Tissue Specificity | This ZC12A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-358 amino acids from the Central region of human ZC12A. |
| Cellular Localization | Cytoplasm (By similarity). Nucleus. |
| Entrez Gene | 80149 |
|---|---|
| Nucleotide Accession | NP_079355.2 |
Application
ZC12A Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ZC12A antibody detected the ZC12A protein (arrow).
Application
ZC12A antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human spleen tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ZC12A antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
ZC12A Antibody (Center) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
