Application
ZFAN5 Antibody (C-term) western blot analysis in MDA-MB468 cell line lysates (35ug/lane).This demonstrates the ZFAN5 antibody detected the ZFAN5 protein (arrow).| Product Name | ZFAN5 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ZA20D2, ZNF216 |
|---|---|
| Alternative Names | ZFAND5 ZA20D2 ZNF216 AN1-type zinc finger protein 5 Zinc finger A20 domain-containing protein 2 Zinc finger protein 216 |
| Molecular Weight(MW) | 23132 Da |
| Function | Involved in protein degradation via the ubiquitin- proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4- induced NF-kappa-B activation in a dose-dependent manner Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation |
| Tissue Specificity | Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly expressed or undetectable in adult brain, heart, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes Expressed in rhabdomyosarcoma RD cells (at protein level) |
| Cellular Localization | Cytoplasm (By similarity). |
| Entrez Gene | 7763 |
|---|---|
| Nucleotide Accession | NP_001095891.1 NP_005998.1 NP_001095890.1 |
Application
ZFAN5 Antibody (C-term) western blot analysis in MDA-MB468 cell line lysates (35ug/lane).This demonstrates the ZFAN5 antibody detected the ZFAN5 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
