Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity)
Tissue Specificity
This ZYX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500~530 amino acids from the C-terminal region of human ZYX.
Cellular Localization
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, focal adhesion. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1
Western blot analysis of ZYX Antibody (C-term) in NCI-H460, T47D cell line lysates (35ug/lane). ZYX (arrow) was detected using the purified Pab.
Application Notes
WB:1:50~100
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.