Application
ACCN3 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ACCN3 antibody detected the ACCN3 protein (arrow).| Product Name | ACCN3 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ASIC3; ACCN3; SLNAC1; TNAC1; Acid-sensing ion channel 3; Amiloride-sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; Testis sodium channel 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ACCN3 SLNAC1 TNAC1 |
|---|---|
| Alternative Names | ASIC3 ACCN3 SLNAC1 TNAC1 Acid-sensing ion channel 3 Amiloride-sensitive cation channel 3 Neuronal amiloride-sensitive cation channel 3 Testis sodium channel 1 |
| Molecular Weight(MW) | 58905 Da |
| Function | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties |
| Tissue Specificity | Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis |
| Cellular Localization | Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm (By similarity). Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity) |
| Entrez Gene | 9311 |
|---|---|
| Nucleotide Accession | NP_064718.1 |
Application
ACCN3 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ACCN3 antibody detected the ACCN3 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
