Application
ADCY10 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ADCY10 antibody detected the ADCY10 protein (arrow).Application
ADCY10 Antibody (Center) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Product Name | ADCY10 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ADCY10; SAC; Adenylate cyclase type 10; AH-related protein; Adenylate cyclase homolog; Germ cell soluble adenylyl cyclase; Testicular soluble adenylyl cyclase |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBFC |
| WB:1:100~500 FC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | SAC |
|---|---|
| Alternative Names | ADCY10 SAC Adenylate cyclase type 10 AH-related protein Adenylate cyclase homolog Germ cell soluble adenylyl cyclase Testicular soluble adenylyl cyclase |
| Molecular Weight(MW) | 187149 Da |
| Function | Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization May be the bicarbonate sensor. Involved in ciliary beat regulation |
| Tissue Specificity | Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone |
| Cellular Localization | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin |
| Entrez Gene | 55811 |
|---|---|
| Nucleotide Accession | NP_001161221.1 NP_060887.2 |
Application
ADCY10 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ADCY10 antibody detected the ADCY10 protein (arrow).
Application
ADCY10 Antibody (Center) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Application Notes | WB:1:100~500 FC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
