ADIPOQ, ACDC, ACRP30, APM1, GBP28, Adiponectin, Gelatin-binding protein
Key Feature
Clonality
Monoclonal
Clone Number
EPR3217
Host Species
Rabbit
Tested Applications
WB
WB:1:2000~20000
Species Reactivity
Human
Concentration
1mg/ml
Target Information
Gene Synonyms
ACDC ACRP30 APM1 GBP28
Alternative Names
ADIPOQ ACDC ACRP30 APM1 GBP28 Adiponectin Gelatin-binding protein
Molecular Weight(MW)
26414 Da
Function
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW
Tissue Specificity
Synthesized exclusively by adipocytes and secreted into plasma