Application
Western blot analysis of anti-AKR7A2 antibody (N-term) in 293 cell line lysates (35ug/lane). AKR7A2 (arrow) was detected using the purified Pab.Western blot analysis of anti-AKR7A2 Antibody (N-term) in mouse liver tissue lysates (35ug/lane). AKR7A2 (arrow) was detected using the purified Pab .| Product Name | AKR7A2 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:50~100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | AFAR, AFAR1, AKR7 |
|---|---|
| Alternative Names | AKR7A2 AFAR AFAR1 AKR7 Aflatoxin B1 aldehyde reductase member 2 AFB1 aldehyde reductase 1 Aldoketoreductase 7 Succinic semialdehyde reductase |
| Molecular Weight(MW) | 39589 Da |
| Function | Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen |
| Tissue Specificity | Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts Detected at low levels in lung and pancreas (at protein level) Widely expressed |
| Cellular Localization | Golgi apparatus (By similarity). Cytoplasm. |
| Entrez Gene | 8574 |
|---|
Application
Western blot analysis of anti-AKR7A2 antibody (N-term) in 293 cell line lysates (35ug/lane). AKR7A2 (arrow) was detected using the purified Pab.Western blot analysis of anti-AKR7A2 Antibody (N-term) in mouse liver tissue lysates (35ug/lane). AKR7A2 (arrow) was detected using the purified Pab .| Application Notes | WB:1:50~100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
