Application
AKR1C4 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the AKR1C4 antibody detected the AKR1C4 protein (arrow).| Product Name | AKR1C4 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CHDR |
|---|---|
| Alternative Names | AKR1C4 CHDR Aldo-keto reductase family 1 member C4 3-alpha-HSD1 3-alpha-hydroxysteroid dehydrogenase type I Chlordecone reductase Dihydrodiol dehydrogenase 4 HAKRA |
| Molecular Weight(MW) | 37067 Da |
| Function | Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route |
| Tissue Specificity | Liver specific. |
| Cellular Localization | Cytoplasm. |
| Entrez Gene | 1109 |
|---|---|
| Nucleotide Accession | NP_001809.2 |
Application
AKR1C4 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the AKR1C4 antibody detected the AKR1C4 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
