Application
ALKBH1 Antibody (C-term) western blot analysis in Jurkat,MCF-7 cell line lysates (35ug/lane).This demonstrates the ALKBH1 antibody detected the ALKBH1 protein (arrow).| Product Name | ALKBH1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ABH, ABH1, ALKBH |
|---|---|
| Alternative Names | ALKBH1 ABH ABH1 ALKBH Alkylated DNA repair protein alkB homolog 1 Alpha-ketoglutarate-dependent dioxygenase ABH1 DNA lyase ABH1 DNA oxidative demethylase ALKBH1 |
| Molecular Weight(MW) | 43832 Da |
| Function | Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron |
| Tissue Specificity | Ubiquitous. |
| Cellular Localization | Mitochondrion. Nucleus (By similarity). Note=Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli (By similarity) |
| Entrez Gene | 8846 |
|---|---|
| Nucleotide Accession | NP_006011.2 |
Application
ALKBH1 Antibody (C-term) western blot analysis in Jurkat,MCF-7 cell line lysates (35ug/lane).This demonstrates the ALKBH1 antibody detected the ALKBH1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
