Application
ALKBH5 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ALKBH5 Antibody detected the ALKBH5 protein (arrow).| Product Name | ALKBH5 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | ABH5, OFOXD1 |
|---|---|
| Alternative Names | ALKBH5 ABH5 OFOXD1 Probable alpha-ketoglutarate-dependent dioxygenase ABH5 Alkylated DNA repair protein alkB homolog 5 |
| Molecular Weight(MW) | 44256 Da |
| Function | Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis |
| Tissue Specificity | Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary |
| Cellular Localization | Nucleus speckle. |
| Entrez Gene | 54890 |
|---|---|
| Nucleotide Accession | NP_060228.3 |
Application
ALKBH5 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ALKBH5 Antibody detected the ALKBH5 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
