Application
ANKS1B Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the ANKS1B antibody detected the ANKS1B protein (arrow).Application
ANKS1B Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ANKS1B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | ANKS1B Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ANKS1B; Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Amyloid-beta protein intracellular domain-associated protein 1; E2A-PBX1-associated protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | ANKS1B Ankyrin repeat and sterile alpha motif domain-containing protein 1B Amyloid-beta protein intracellular domain-associated protein 1 E2A-PBX1-associated protein |
|---|---|
| Molecular Weight(MW) | 138066 Da |
| Function | Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing |
| Tissue Specificity | Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines |
| Cellular Localization | Cytoplasm. Isoform 3: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. Note=The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity) Isoform 6: Nucleus. |
| Entrez Gene | 56899 |
|---|---|
| Nucleotide Accession | NP_064525.1 NP_690001.3 |
Application
ANKS1B Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the ANKS1B antibody detected the ANKS1B protein (arrow).
Application
ANKS1B Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ANKS1B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
