Application
AP3B2 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the AP3B2 antibody detected the AP3B2 protein (arrow).| Product Name | AP3B2 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AP3B2; AP-3 complex subunit beta-2; Adapter-related protein complex 3 subunit beta-2; Adaptor protein complex AP-3 subunit beta-2; Beta-3B-adaptin; Clathrin assembly protein complex 3 beta-2 large chain; Neuron-specific vesicle coat protein beta-NAP |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | AP3B2 AP-3 complex subunit beta-2 Adapter-related protein complex 3 subunit beta-2 Adaptor protein complex AP-3 subunit beta-2 Beta-3B-adaptin Clathrin assembly protein complex 3 beta-2 large chain Neuron-specific vesicle coat protein beta-NAP |
|---|---|
| Molecular Weight(MW) | 119059 Da |
| Function | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals |
| Tissue Specificity | Expression is specific to nervous system. Expressed in nerve terminal and cell body, and is associated with nerve-terminal vesicles. Expression seen in Purkinje cells, cortical neurons, neuroectodermal tumors and graded in cerebral cortex (deeper layers exhibit stronger expression) |
| Cellular Localization | Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Golgi apparatus (By similarity) Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (By similarity) |
| Entrez Gene | 8120 |
|---|---|
| Nucleotide Accession | NP_004635.2 |
Application
AP3B2 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the AP3B2 antibody detected the AP3B2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
