Application
APOB48R Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the APOB48R antibody detected the APOB48R protein (arrow).| Product Name | APOB48R Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | APOBR; APOB48R; Apolipoprotein B receptor; Apolipoprotein B-100 receptor; Apolipoprotein B-48 receptor |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | APOB48R |
|---|---|
| Alternative Names | APOBR APOB48R Apolipoprotein B receptor Apolipoprotein B-100 receptor Apolipoprotein B-48 receptor |
| Molecular Weight(MW) | 114820 Da |
| Function | Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP) Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages |
| Tissue Specificity | Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells |
| Cellular Localization | Cell membrane; Peripheral membrane protein. Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein |
| Nucleotide Accession | NP_061160.2 |
|---|
Application
APOB48R Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the APOB48R antibody detected the APOB48R protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
