Application
APOBEC3D Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the APOBEC3D antibody detected the APOBEC3D protein (arrow).| Product Name | APOBEC3D Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | APOBEC3D; Probable DNA dC->dU-editing enzyme APOBEC-3D |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | APOBEC3D Probable DNA dC->dU-editing enzyme APOBEC-3D |
|---|---|
| Molecular Weight(MW) | 46598 Da |
| Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons |
| Tissue Specificity | Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung |
| Cellular Localization | Cytoplasm. Cytoplasm, P-body. |
| Entrez Gene | 140564 |
|---|---|
| Nucleotide Accession | NP_689639.2 |
Application
APOBEC3D Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the APOBEC3D antibody detected the APOBEC3D protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
