Application
APOBEC3C Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the APOBEC3C antibody detected the APOBEC3C protein (arrow).| Product Name | APOBEC3C Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | APOBEC3C; APOBEC1L; PBI; Probable DNA dC->dU-editing enzyme APOBEC-3C; APOBEC1-like; Phorbolin I |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | APOBEC1L PBI |
|---|---|
| Alternative Names | APOBEC3C APOBEC1L PBI Probable DNA dC->dU-editing enzyme APOBEC-3C APOBEC1-like Phorbolin I |
| Molecular Weight(MW) | 22826 Da |
| Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation |
| Tissue Specificity | Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary |
| Cellular Localization | Nucleus. Cytoplasm. |
| Entrez Gene | 27350 |
|---|---|
| Nucleotide Accession | NP_055323.2 |
Application
APOBEC3C Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the APOBEC3C antibody detected the APOBEC3C protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
