Application
ARHGEF4 Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the ARHGEF4 antibody detected the ARHGEF4 protein (arrow).| Product Name | ARHGEF4 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ARHGEF4; KIAA1112; Rho guanine nucleotide exchange factor 4; APC-stimulated guanine nucleotide exchange factor 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1112 |
|---|---|
| Alternative Names | ARHGEF4 KIAA1112 Rho guanine nucleotide exchange factor 4 APC-stimulated guanine nucleotide exchange factor 1 |
| Molecular Weight(MW) | 79067 Da |
| Function | Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression |
| Tissue Specificity | Expressed at high levels in the brain, skeletal muscle and testis and at low levels in the kidney, lung, small intestine, ovary and prostate. Expression is aberrantly enhanced in most colorectal tumors |
| Cellular Localization | Isoform 3: Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Note=Associated with membrane ruffles (Probable) |
| Entrez Gene | 50649 |
|---|---|
| Nucleotide Accession | NP_056135.2 |
Application
ARHGEF4 Antibody (C-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the ARHGEF4 antibody detected the ARHGEF4 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
