Application
Western blot analysis of anti-ARTS1 Antibody (Center) in Ramos cell line lysates (35ug/lane). ARTS1 (arrow) was detected using the purified Pab.| Product Name | ARTS1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ERAP1; APPILS; ARTS1; KIAA0525; Endoplasmic reticulum aminopeptidase 1; ARTS-1; Adipocyte-derived leucine aminopeptidase; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; Type 1 tumor necrosis factor receptor shedding aminopeptida |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:50~100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | APPILS ARTS1 KIAA0525 |
|---|---|
| Alternative Names | ERAP1 APPILS ARTS1 KIAA0525 Endoplasmic reticulum aminopeptidase 1 ARTS-1 Adipocyte-derived leucine aminopeptidase Aminopeptidase PILS Puromycin-insensitive leucyl-specific aminopeptidase Type 1 tumor necrosis factor receptor shedding aminopeptida |
| Molecular Weight(MW) | 107235 Da |
| Function | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney |
| Tissue Specificity | Ubiquitous. |
| Cellular Localization | Endoplasmic reticulum membrane; Single-pass type II membrane protein (Probable) |
| Entrez Gene | 51752 |
|---|
Application
Western blot analysis of anti-ARTS1 Antibody (Center) in Ramos cell line lysates (35ug/lane). ARTS1 (arrow) was detected using the purified Pab.| Application Notes | WB:1:50~100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
