Application
A. Western blot analysis of anti-ASIP RabMAb (Cat. #AJ1061a), dilution 1:500. A: LNCap B: Hela C: A431 D: MCF-7| Product Name | ASIP Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP310Y |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | PAR3, PAR3A |
|---|---|
| Alternative Names | PARD3 PAR3 PAR3A Partitioning defective 3 homolog CTCL tumor antigen se2-5 PAR3-alpha |
| Molecular Weight(MW) | 151423 Da |
| Function | Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons |
| Tissue Specificity | Widely expressed. |
| Cellular Localization | Endomembrane system. Cell junction. Cell junction, tight junction. Cell membrane. Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction |
| Entrez Gene | 56288 |
|---|
Application
A. Western blot analysis of anti-ASIP RabMAb (Cat. #AJ1061a), dilution 1:500. A: LNCap B: Hela C: A431 D: MCF-7| Application Notes | WB:1:500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
