Application
ATXN7 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ATXN7 antibody detected the ATXN7 protein (arrow).| Product Name | ATXN7 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | SCA7 |
|---|---|
| Alternative Names | ATXN7 SCA7 Ataxin-7 Spinocerebellar ataxia type 7 protein |
| Molecular Weight(MW) | 95451 Da |
| Function | Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation Necessary for microtubule cytoskeleton stabilization |
| Tissue Specificity | Isoform a and isoform b are expressed in CNS, but isoform a is expressed predominantly in the peripherical tissues. Isoform b is also highly expressed in the frontal lobe, skeletal muscle and spinal cord and is expressed at a lower level in the lung, lymphoblast and intestine |
| Cellular Localization | Isoform a: Nucleus. Nucleus, nucleolus. Nucleus matrix. Cytoplasm, cytoskeleton. Note=In addition to a diffuse distribution throughout the nucleus, it is associated with the nuclear matrix and the nucleolus. It is able to shuttle between the nucleus and cytoplasm |
| Entrez Gene | 6314 |
|---|---|
| Nucleotide Accession | NP_000324.1 NP_001170858.1 |
Application
ATXN7 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ATXN7 antibody detected the ATXN7 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
