Application
AWAT2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the AWAT2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.Application
AWAT2 Antibody (C-term) western blot analysis in mouse liver,spleen tissue lysates (35ug/lane).This demonstrates the AWAT2 antibody detected the AWAT2 protein (arrow).| Product Name | AWAT2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| IHC:1:50~100 WB |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DC4, DGAT2L4, MFAT, WS |
|---|---|
| Alternative Names | AWAT2 DC4 DGAT2L4 MFAT WS Acyl-CoA wax alcohol acyltransferase 2 Acyl-CoA retinol O-fatty-acyltransferase Diacylglycerol O-acyltransferase 2-like protein 4 Diacylglycerol O-acyltransferase candidate 4 Long-chain-alcohol O-fatty-acyltransferase 2 |
| Molecular Weight(MW) | 38094 Da |
| Function | Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl- CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo |
| Tissue Specificity | Abundant in tissues rich in sebaceous glands such as the preputial gland and eyelid. Highly expressed in skin, where it is primarily restricted to undifferentiated peripheral sebocytes. Also expressed at lower level in other tissues except pancreas |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Entrez Gene | 158835 |
|---|---|
| Nucleotide Accession | NP_001002254.1 |
Application
AWAT2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the AWAT2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
AWAT2 Antibody (C-term) western blot analysis in mouse liver,spleen tissue lysates (35ug/lane).This demonstrates the AWAT2 antibody detected the AWAT2 protein (arrow).| Application Notes | IHC:1:50~100 WB |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
