Application
AZU1 Antibody (Center) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the AZU1 antibody detected the AZU1 protein (arrow).Application
Western blot analysis of AZU1 (arrow) using rabbit polyclonal AZU1 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the AZU1 gene.| Product Name | AZU1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | AZU1 Azurocidin Cationic antimicrobial protein CAP37 Heparin-binding protein |
|---|---|
| Molecular Weight(MW) | 26886 Da |
| Function | This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G |
| Tissue Specificity | This AZU1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-96 amino acids from the Central region of human AZU1. |
| Cellular Localization | Cytoplasmic granule. Note=Cytoplasmic granules of neutrophils |
| Entrez Gene | 566 |
|---|---|
| Nucleotide Accession | NP_001691.1 |
Application
AZU1 Antibody (Center) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the AZU1 antibody detected the AZU1 protein (arrow).
Application
Western blot analysis of AZU1 (arrow) using rabbit polyclonal AZU1 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the AZU1 gene.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
