Application
BAZ1B Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the BAZ1B antibody detected the BAZ1B protein (arrow).| Product Name | BAZ1B Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | WBSC10, WBSCR10, WBSCR9, WSTF |
|---|---|
| Alternative Names | BAZ1B WBSC10 WBSCR10 WBSCR9 WSTF Tyrosine-protein kinase BAZ1B Bromodomain adjacent to zinc finger domain protein 1B Williams syndrome transcription factor Williams-Beuren syndrome chromosomal region 10 protein Williams-Beuren syndrome chromosomal |
| Molecular Weight(MW) | 170903 Da |
| Function | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. In the WINAC complex, plays an essential role by targeting the complex to acetylated histones, an essential step for VDR-promoter association |
| Tissue Specificity | Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary |
| Cellular Localization | Nucleus. Note=Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA |
| Entrez Gene | 9031 |
|---|---|
| Nucleotide Accession | NP_115784.1 |
Application
BAZ1B Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the BAZ1B antibody detected the BAZ1B protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
