Application
Western blot analysis of BCOR Antibody (Center S1122) (Cat.# AP7359c) in 293 cell line lysates (35ug/lane). BCOR (arrow) was detected using the purified Pab.Application
Western blot analysis of BCOR Antibody (Center S1122) (Cat.# AP7359c) in mouse stomach tissue lysates (35ug/lane). BCOR (arrow) was detected using the purified Pab.Application
BCOR Antibody (Center S1122) (Cat.# AP7359c) IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the BCOR Antibody (Center S1122) for immunohistochemistry. Clinical relevance has not been evaluated.Application
BCOR Antibody (Center S1122) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Product Name | BCOR Antibody (Center S1122) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BCOR; KIAA1575; BCL-6 corepressor |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHCFC |
| WB:1:50~100 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1575 |
|---|---|
| Alternative Names | BCOR KIAA1575 BCL-6 corepressor |
| Molecular Weight(MW) | 192189 Da |
| Function | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2) |
| Tissue Specificity | Ubiquitously expressed. |
| Cellular Localization | Nucleus. |
| Entrez Gene | 54880 |
|---|
Application
Western blot analysis of BCOR Antibody (Center S1122) (Cat.# AP7359c) in 293 cell line lysates (35ug/lane). BCOR (arrow) was detected using the purified Pab.
Application
Western blot analysis of BCOR Antibody (Center S1122) (Cat.# AP7359c) in mouse stomach tissue lysates (35ug/lane). BCOR (arrow) was detected using the purified Pab.
Application
BCOR Antibody (Center S1122) (Cat.# AP7359c) IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the BCOR Antibody (Center S1122) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
BCOR Antibody (Center S1122) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Application Notes | WB:1:50~100 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
