Application
BLOC1S2 Antibody (Center) western blot analysis in HepG2 cell line lysates (15ug/lane).This demonstrates the BLOC1S2 antibody detected the BLOC1S2 protein (arrow).Application
BLOC1S2 Antibody (Center) western blot analysis in mouse NIH-3T3 cell line lysates (15ug/lane).This demonstrates the BLOC1S2 antibody detected the BLOC1S2 protein (arrow).Application
BLOC1S2 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervix carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the BLOC1S2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.Application
BLOC1S2 Antibody (Center) flow cytometric analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Product Name | BLOC1S2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BLOC1S2; BLOS2; CEAP; Biogenesis of lysosome-related organelles complex 1 subunit 2; Centrosome-associated protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHCFC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | BLOS2 CEAP |
|---|---|
| Alternative Names | BLOC1S2 BLOS2 CEAP Biogenesis of lysosome-related organelles complex 1 subunit 2 Centrosome-associated protein |
| Molecular Weight(MW) | 15961 Da |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May play a role in cell proliferation |
| Tissue Specificity | Isoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues (at protein level) |
| Cellular Localization | Cytoplasm, cytoskeleton, centrosome. Note=Localizes to the centrosomes in a microtubule-dependent manner |
| Entrez Gene | 282991 |
|---|---|
| Nucleotide Accession | NP_776170.2 |
Application
BLOC1S2 Antibody (Center) western blot analysis in HepG2 cell line lysates (15ug/lane).This demonstrates the BLOC1S2 antibody detected the BLOC1S2 protein (arrow).
Application
BLOC1S2 Antibody (Center) western blot analysis in mouse NIH-3T3 cell line lysates (15ug/lane).This demonstrates the BLOC1S2 antibody detected the BLOC1S2 protein (arrow).
Application
BLOC1S2 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervix carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the BLOC1S2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
BLOC1S2 Antibody (Center) flow cytometric analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
