Application
BRMS1 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the BRMS1 antibody detected the BRMS1 protein (arrow).| Product Name | BRMS1 (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BRMS1; Breast cancer metastasis-suppressor 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | BRMS1 Breast cancer metastasis-suppressor 1 |
|---|---|
| Molecular Weight(MW) | 28461 Da |
| Function | Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma |
| Tissue Specificity | Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies |
| Cellular Localization | Nucleus. Cytoplasm. Note=Predominantly nuclear |
| Entrez Gene | 25855 |
|---|---|
| Nucleotide Accession | NP_056214.1 |
Application
BRMS1 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the BRMS1 antibody detected the BRMS1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
